| Popis: |
Recently, molecular typing approaches have advanced significantly through the availability of whole genome sequence data, allied with high-throughput microarray technologies and sophisticated data analysis. This has enabled us to pinpoint individual genes that may be important in survival, virulence and niche adaptation. This chapter will describe how comparative phylogenomics can be used to model relationships between strains and their genetic content, their origin (e.g. food source) and their virulence potential/disease outcome. Examples will be drawn from the established foodborne pathogens Campylobacter jejuni, the enteropathogenic Yersiniae and Listeria monocytogenes, as well as the suspected food-associated pathogen Clostridium difficile. |
