Brain endocannabinoids modulate lung Inflammation during sepsis (1157.4)

Autor:	Vincenzo Russo, Arnold Johnson, Nancy Gertzberg, Carlos Feleder, Paul Neumann, Jianya Peng
Rok vydání:	2014
Předmět:	Cannabinoid receptor Chemistry Septic shock Inflammation Lung injury Pharmacology medicine.disease Biochemistry Sepsis IκBα Genetics medicine TLR4 lipids (amino acids peptides and proteins) medicine.symptom Receptor Molecular Biology Biotechnology
Zdroj:	The FASEB Journal. 28
ISSN:	1530-6860 0892-6638
DOI:	10.1096/fasebj.28.1_supplement.1157.4
Popis:	Sepsis is a systemic inflammatory response caused by infection which can lead to shock and lung injury. Previous studies indicate that septic shock is mediated by brain endocannabinoid 1 (CB1) receptors. Hence, this study tested the hypothesis that the brain CB1 receptors regulate LPS-induced lung inflammation. Male Sprague-Dawley rats received an intracerebroventricular (ICV) injection of either the CB1 receptor antagonist Rimonabant (2 µg/kg) or vehicle, 5 minutes prior to IV injection of either LPS (5 mg/kg) or saline. Lungs were removed 0.5 h or 4 h after IV injection of LPS and isolated for assessment of pulmonary capillary pressure (Ppc), lung wet/dry weight ratio (W/D), TLR4 activation, α7nicotinic acetylcholine (α7nAch) pathway, IL-6 and VCAM. LPS- 0.5 h induced a decrease in lung levels of IRAK1 and IκBα indicating activation of TLR4, and decreased phosphorylated Src-Y416 family kinases (pSFK) and phosphorylated Raf1-S259 (pRaf1) suggesting decreased α7nAch signaling all which were prevented by R...
Databáze:	OpenAIRE
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