| Autor: |
Masaki IKEDA, Yojiro Yutaka, Toyofumi Chen-Yoshikawa, Michio Tanaka, Masaki Yamamoto, Satona Tanaka, Yoshito Yamada, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Akihiko Yoshizawa, Eishi Kusaka, Miki Nagao, Hiroshi Date |
| Rok vydání: |
2023 |
| Popis: |
Dissolved ozone is generally used for sanitization, but it has not been used for thoracic cavity sanitization because of its short half-life (Staphylococcus aureus colonies were counted after exposure to ozone-UFB or non-UFB ozone at the same ozone concentration (0.4 mg/L). The colony count was significantly lower in the ozone-UFB group than in the non-UFB ozone group (p = 0.034). The effect of repeated pleural irrigation using ozone-UFB and saline was compared in a rat empyema model of S. aureus infection. The bacterial count in the pleural effusion was decreased by at least 5-fold following intrathoracic lavage with ozone-UFB (3 mg/L). To examine the safety of ozone-UFB for intrathoracic use, ozone-UFB with a higher ozone concentration (10 mg/L) was injected into the thoracic cavities of normal rats. The treatment did not result in any specific pleural damage or elevated serum interleukin-6 concentrations. The findings highlighted the efficacy and safety of ozone-UFB for intrathoracic sanitization, but further studies are needed to determine the optimal therapeutic ozone concentration with appropriate safety margins. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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