Integrated modelling of lysozyme ultrafiltration

Autor:	Vitor Magueijo, Maria Norberta de Pinho, Viriato Semiao
Rok vydání:	2006
Předmět:	Ternary numeral system Chemistry Sodium Analytical chemistry Ultrafiltration chemistry.chemical_element Filtration and Separation Permeation Biochemistry chemistry.chemical_compound Membrane Mass transfer General Materials Science Physical and Theoretical Chemistry Lysozyme Bar (unit)
Zdroj:	Journal of Membrane Science. 286:133-143
ISSN:	0376-7388
Popis:	Ultrafiltration of a ternary system lysozyme/sodium chloride/water is modelled through the integration of the surface force-pore flow (SFPF) model with the feed flow transport equations and recurring to computational fluid dynamics (CFD). Permeation experiments are performed using an ultrafiltration laboratory cell with a slit feed channel (h = 1.2 mm ≪ l = 200 mm, w = 30 mm) and a laboratory-made cellulose acetate membrane characterized by an hydraulic permeability of 5.9 × 10-11 m s-1 Pa-1 and a molecular weight cut-off of 60 kDa. The operating pressures ranged from 2 to 8 bar and the salt concentrations from 6 × 10-4 to 0.1 M. The ultrafiltration performance is simulated at different operating pressures and salt concentrations through multicomponent mass transfer modelling with incorporation of membrane/protein electrostatic interactions. The predictions of the lysozyme apparent rejection coefficients and permeation fluxes are in very good agreement with the experimental results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::470cd97c098d2cb176ef559a538103ec https://doi.org/10.1016/j.memsci.2006.09.027 Zobrazit plný text záznamu Full Text from ScienceDirect