Synthesis and study of new derivatives of 6-[methoxy(phenyl)methyl]-2-(nitroamino)pyrimidin-4(3H)-one

Autor:	I. Yu. Kameneva, Boris S. Orlinson, M. B. Nawrozkij, E. K. Zakharova, Ivan A. Novakov
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Nitroguanidine Chemistry Stereochemistry Regioselectivity Organic chemistry General Chemistry Mandelic acid
Zdroj:	Russian Chemical Bulletin. 62:138-141
ISSN:	1573-9171 1066-5285
DOI:	10.1007/s11172-013-0020-6
Popis:	New 6-[(2,6-dihalophenyl)(methoxy)methyl]-5-methyl-2-(nitroamino)pyrimidin-4(3H)-ones were synthesized by an original and efficient method involving regioselective O,O′-dimethylation of substituted mandelic acids in superbasic medium. The compounds obtained can serve as precursors to a novel series of non-nucleoside HIV-1 replication inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::46f5a88f5ea2f5c1ce61a76f8fba3382 https://doi.org/10.1007/s11172-013-0020-6 Zobrazit plný text záznamu Full text from SpringerLink