Lymph node metastasis as a new target for cancer treatment
Autor: | Michel Kraemer, Jean Luc Breau, Jean François Bernaudin, Pierre Saintigny, Jean F. Morere |
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Rok vydání: | 2006 |
Předmět: |
Cancer Research
Pathology medicine.medical_specialty biology business.industry medicine.disease Lymphangiogenesis Metastasis Vascular endothelial growth factor chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Vascular endothelial growth factor C biology.protein medicine Cancer research Pharmacology (medical) Growth factor receptor inhibitor Hepatocyte growth factor business Lymph node Platelet-derived growth factor receptor medicine.drug |
Zdroj: | Targeted Oncology. 2:49-57 |
ISSN: | 1776-260X 1776-2596 |
DOI: | 10.1007/s11523-006-0037-y |
Popis: | The presence of lymph node metastasis is predictive of poor prognosis in solid tumors. Demonstration of specific markers of lymphatic endothelial cells has facilitated the study of the molecular mechanisms of metastasis, particularly lymphangiogenesis. The vascular endothelial growth factor (VEGF)-C/VEGF-D/VEGF receptor (VEGFR)-3 axis has been the most extensively studied, but other molecular pathways are also involved, such as fibroblast growth factor (FGF)-2, platelet-derived growth factor (PDGF)-BB, angiopoietin-1, VEGF-A, hepatocyte growth factor (HGF), insulin-like growth factor (IGF)-1 and -1R, and cyclooxygenase-2. Several strategies are currently being developed to prevent lymphatic metastasis, mainly targeting the VEGF-C/VEGF-D/VEGFR-3 axis: inhibiting maturation and activation of VEGF-C and VEGF-D by successive proteolyses, inhibiting binding of ligands to their receptor, and using tyrosine kinase inhibitors. Many questions remain and will be discussed in this article, particularly the role of lymph node metastasis in the development of visceral metastases, possible toxicities of antilymphangiogenic treatments, and their possible interactions with intratumoral penetration of other anticancer agents. |
Databáze: | OpenAIRE |
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