Effect of Repeated Small-Dose .GAMMA.-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice

Autor:	Su-Ping Fang, Fumitoshi Tago, Shuji Kojima, Noriko Simura, Yasuko Muto
Rok vydání:	2006
Předmět:	medicine.medical_specialty Chemistry Helper T lymphocyte Health Toxicology and Mutagenesis Atopic dermatitis Toxicology medicine.disease Endocrinology Immune system Immunity Interferon Internal medicine Immunology medicine Irradiation γ ray irradiation Interleukin 4 medicine.drug
Zdroj:	Journal of Health Science. 52:406-411
ISSN:	1347-5207 1344-9702
Popis:	We previously showed that several small-dose 0.5 Gy whole-body γ-ray irradiation inhibits tumor growth in mice via elevation of the interferon (IFN)-γ/interleukin 4 (IL-4) ratio concomitantly with a decrease in the percentage of B cells. Here, we examined whether repeated small-dose (0.5 Gy, 10 times) γ-ray irradiation influences atopic dermatitis in an NC/Nga mouse model. It was found that repeated γ-ray irradiation increased total IgE in comparison with the disease-control group. Levels of IL-4 and IL-5 were increased versus the disease-control group, while IFN-γ was slightly decreased, resulting in a further decrease of the IFN-γ/IL-4 ratio compared with the disease-control group. These results indicate that repeated small-dose γ-ray irradiation may exacerbate atopic dermatitis. This may be because the irradiation induces not helper T lymphocyte 1 (Th1), but Th2 polarization in this atopic mouse model, i.e., the effects of small-dose irradiation may be different in conditions involving immune hypersensitivity and impaired immunity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::46ef58ab18c5333b43417cdc6938bdf5 https://doi.org/10.1248/jhs.52.406 Zobrazit plný text záznamu