Brief Communication: Gallium-67 Citrate Uptake by Cultured Tumor Cells, Stimulated by Serum Transferrin234

Autor:	R. G. Sephton, A. W. Harris
Rok vydání:	1975
Předmět:	chemistry.chemical_classification Cancer Research medicine.medical_specialty Tumor cells Stimulation Biology medicine.disease Tissue culture Endocrinology Oncology Biochemistry chemistry Transferrin In vivo Internal medicine medicine Neoplasm Mouse tumor Gallium 67 citrate
Zdroj:	JNCI: Journal of the National Cancer Institute. 54:1263-1266
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/54.5.1263
Popis:	The uptake of the tumor scanning agent 67-Ga citrate by cultured mouse tumor cells wqs greatly enhanced with small additons of certain sera to the culture medium. This stimulation of uptake was due to a macromolecular serum component, provisionally identified with transferrin. The response under optimum conditions was so great as to suggest that the 67-Ga uptake process depends entirely on the action of transferrin. The same mechanism probably operates in vivo and may help explain interesting features of the tracer's tissue distribution, particularly its tumor affinity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::46edc1115e13306ca12a6a3e95d8f5bb https://doi.org/10.1093/jnci/54.5.1263 Zobrazit plný text záznamu