Coupled CFD-DEM model for dry powder inhalers simulation: Validation and sensitivity analysis for the main model parameters
| Autor: | R. Da Vià, Andrea Benassi, Ciro Cottini, Simone Bnà, R. Ponzini |
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| Rok vydání: | 2021 |
| Předmět: |
Computer science
business.industry General Chemical Engineering Airflow Experimental data 02 engineering and technology Mechanics Computational fluid dynamics 021001 nanoscience & nanotechnology 020401 chemical engineering Dry powder Verification and validation of computer simulation models CFD-DEM model Sensitivity (control systems) 0204 chemical engineering 0210 nano-technology business Aerosolization |
| Zdroj: | Powder Technology. 385:199-226 |
| ISSN: | 0032-5910 |
| DOI: | 10.1016/j.powtec.2021.02.044 |
| Popis: | The use of computational techniques in the design of dry powder inhalers (DPI), as well as in unravelling the complex mechanisms of drug aerosolization, has increased significantly in recent years. Computational fluid dynamics (CFD) is used to study the air flow, inside the DPI, during the patient inspiratory act while discrete element methods (DEM) are used to simulate the dispersion and aerosolization of the drug product powder particles. In this work we discuss the possibility to validate a coupled CFD-DEM model for the NextHaler® DPI device against previously published experimental data. The approximations and assumptions made are deeply discussed. The comparison between computational and experimental results is detailed both for fluid and powder flows. Finally, the potential and possible applications of a calibrated DPI model are discussed as well as the missing elements necessary to achieve a fully quantitative predictive computational model. |
| Databáze: | OpenAIRE |
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