Long-Term Visual Outcomes in Neovascular Age-Related Macular Degeneration Eyes With Baseline Macular Atrophy on Anti-Vascular Endothelial Growth Factor Treatment
| Autor: | Michael J. Foster, Jacqueline Shaia, Christopher M. Maatouk, Catherine A. Urbano, Mark T. Bui, Grant L. Hom, Blanche L. Kuo, Rishi P. Singh, Katherine E. Talcott |
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| Rok vydání: | 2023 |
| Zdroj: | Ophthalmic Surgery, Lasers and Imaging Retina. 54:223-230 |
| ISSN: | 2325-8179 2325-8160 |
| Popis: | Background and Objective: This study explores the connection between macular atrophy (MA) status at baseline and best visual acuity (BVA) after 5 to 7 years of anti-vascular endothelial growth factor (anti-VEGF) injections on eyes with neovascular age-related macular degeneration (nAMD). Patients and Methods: This retrospective study included patients with neovascular age-related macular degeneration receiving anti-VEGF injections at least twice-yearly for 5+ years at Cole Eye Institute. Analyses of variance and linear regressions explored the connection between MA status, baseline MA intensity, and 5-year BVA change. Results: Of 223 included patients, 5-year BVA change was not statistically significant between MA status groups or from baseline. The population's average 7-year BVA change was −6.3 Early Treatment Diabetic Retinopathy Study letters. Type and frequency of anti-VEGF injections were comparable between MA status groups ( P > 0.05). Conclusion: Regardless of MA status, 5- and 7-year BVA change lacked clinical relevance. If receiving regular treatment for 5+ years, patients with baseline MA achieve comparable visual outcomes to those without MA, with similar treatment and visit burdens. [ Ophthalmic Surg Lasers Imaging Retina 2023;54:223–230.] |
| Databáze: | OpenAIRE |
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