Comparative determination of photodegradation kinetics of quinolones
| Autor: | C. Pessoa, Ana M. Cárdenas, María Eliana Hidalgo, Ernesto Fernández |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Nalidixic acid
Chemistry medicine.drug_class General Chemical Engineering General Physics and Astronomy Quantum yield Pipemidic acid General Chemistry Photochemistry Quinolone Oxolinic acid medicine Rosoxacin High performance thin layer chromatography Antibacterial agent medicine.drug Nuclear chemistry |
| Zdroj: | Journal of Photochemistry and Photobiology A: Chemistry. 73:135-138 |
| ISSN: | 1010-6030 |
| DOI: | 10.1016/1010-6030(93)80042-8 |
| Popis: | The photostabilities of several quinolones have been determined using high performance thin layer chromatography. On irradiation with UVA (350 nm), the photostability decreases in the order: ciprofloxacin (CP)> norfloxacin (NF) > pipemidic acid (PA) > nalidixic acid (NA) > M-193324 > rosoxacin (RS) > oxolinic acid (OA). The photo- degradation process in all cases follows first-order kinetics. Furthermore, the quantum yield of fluorescence was determined for each quinolone; these values vary from 0.15 x 10 −2 to 5.15 x 10 −2 . The highest Φ f value corresponds to CP and NF. These results show that quinolones which possess a piperazine ring at the C-7 position (CP, NF, PA) are less photostable and more fluorescent. |
| Databáze: | OpenAIRE |
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