The association between HLA DQ genetic polymorphism and type 1 diabetes

Autor: Horacio Cardoso, José Luis Santos, Gerardo Javiel, Adriana Mimbacas, Carmen Pisciottano, Rosario Grignola, Ana María Jorge, Fernando Pérez-bravo
Rok vydání: 2004
Předmět:
Zdroj: European Journal of Epidemiology. 19:931-934
ISSN: 1573-7284
0393-2990
DOI: 10.1007/s10654-004-5176-9
Popis: Susceptibility to the type 1 diabetes is genetically controlled and there is an increased risk associated with the presence of some specific alleles of the human leukocyte antigens class II loci (DQA1 and DQB1 genes). The purpose of this study is to evaluate the association between type 1 diabetes and HLA DQ alleles using case-parents trios in the admixed population of Uruguay composed by a mixture of Caucasian, Amerindian and Negroid populations. DQA1 and DQB1 genotyping was performed by polimerase chain reaction followed by oligospecific probes hybridization in 51 case-parents trios. The transmission disequilibrium test was used for detecting differential transmission in the HLA DQ loci. DQB1*0302 was the only allele for which preferential transmission is suggested (probability of transmission=67.56%; exact p-value TDT=0.047 uncorrected for multiple comparisons). DQA1*0301 allele showed a trend for preferential transmission without achieving statistical significance. This result would confirm the hypothesis previously advanced in a case-control study. Therefore, DQB1*0302 allele could be considered as the most important susceptibility allele for developing type 1 diabetes in Uruguay population.
Databáze: OpenAIRE
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