Waldenström's macroglobulinemia in a dog with a bleeding diathesis
| Autor: | Laetitia Jaillardon, C. Fournel-Fleury |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Rouleaux
medicine.medical_specialty Proteinuria General Veterinary Chlorambucil medicine.diagnostic_test business.industry Hyperglobulinemia Macroglobulinemia Neutropenia medicine.disease Gastroenterology Bleeding diathesis hemic and lymphatic diseases Internal medicine Immunology medicine medicine.symptom business medicine.drug Partial thromboplastin time |
| Zdroj: | Veterinary Clinical Pathology. 40:351-355 |
| ISSN: | 0275-6382 |
| Popis: | An 11-year-old female spayed Whippet dog was referred to the Veterinary Hospital of the National Veterinary School of Lyon with a 3-month history of chronic bleeding, cutaneous masses suggestive of hematomas, and hemorrhagic diarrhea. Laboratory abnormalities included leukopenia with neutropenia and lymphopenia, rouleaux formation, marked hyperproteinemia with hyperglobulinemia and normoalbuminemia, hypercalcemia, markedly increased serum urea concentration, mildly increased creatinine concentration, and proteinuria. Hemostatic screening tests showed marked prolongation of thrombin time, increased concentrations of fibrin(ogen) degradation products and D-dimers, and slightly prolonged activated partial thromboplastin time. Serum and urine protein electrophoresis revealed a monoclonal peak identified as IgM by immunoelectrophoresis and an M-spike, respectively. Cytologic evaluation of bone marrow revealed a hypocellular sample with lymphoplasmacytic cells comprising approximately 50% of all nucleated cells. These findings were consistent with a diagnosis of Waldenstrom's macroglobulinemia with secondary bleeding diathesis. Treatment with prednisone and chlorambucil was initiated, and the dog had a good response. |
| Databáze: | OpenAIRE |
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