Antifungal Activity of Chromolaena odorata (L.) King & Robinson(Asteraceae) of Cameroon

Autor:	A. Ngono Ngane, F. Ndifor, Ph. Bouchet, L. Biyiti, R M Ebelle Etame, P.H. Amvam Zollo
Rok vydání:	2006
Předmět:	Pharmacology Antifungal biology medicine.drug_class Chromolaena odorata General Medicine Aqueous ethanol Asteraceae Pharmacognosy biology.organism_classification Infectious Diseases Oncology Drug Discovery Botany medicine Pharmacology (medical)
Zdroj:	Chemotherapy. 52:103-106
ISSN:	1421-9794 0009-3157
Popis:	An aqueous ethanol extract of leaves of Chromolaena odorata and some of its fractions were examined for their antifungal properties by dilution methods on solid and liquid media, using yeasts and filamentous fungi. Extract and fractions inhibit the in vitro growth of Cryptococcus neoformans, Microsporum gypseum, Trichophyton mentagrophytes and Trichophyton rubrum with a minimal inhibitory concentration range from 62.5 to 500 µg/ml for the extract and from 25 to 100 µg/ml for fractions. A qualitative chemical analysis of the extract and fractions showed the presence of biologically active constituents such as some coumarins, flavonoids, phenols, tannins and sterols. No toxic effect was observed in mice treated per os with the extract. This study provides a scientific confirmation of the use of Chromolaena odorata in traditional medicine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::46c4264bc156fee0e7a8280421c2f81e https://doi.org/10.1159/000092373 Zobrazit plný text záznamu