Alterações encontradas na angiografia por tomografia de coerência óptica (OCT-A) em pacientes com síndrome de Alport
| Autor: | Laisa Gallon, Flávio Gusmão Trancoso, Fabiano Cade, Antônio Fábio Miguel da Silva, Fernando Roberte Zanetti, Maria Luiza de Azevedo Bomfim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Retina
medicine.medical_specialty Visual acuity medicine.diagnostic_test business.industry Retinal General Medicine medicine.disease Fluorescein angiography Anterior lenticonus Ophthalmology Quadrant (abdomen) chemistry.chemical_compound medicine.anatomical_structure Macula Lutea chemistry Medicine medicine.symptom Alport syndrome business |
| Zdroj: | Arquivos Brasileiros de Oftalmologia. 83 |
| ISSN: | 0004-2749 |
| DOI: | 10.5935/0004-2749.20200088 |
| Popis: | Purpose: To describe the findings on optical coherence tomography angiography associated with Alport syndrome. Methods: Descriptive study from a referral ophthalmology service (Hospital Evangelico de Vila Velha, Brazil). Patients diagnosed with Alport syndrome were included. Results: The study group consisted of four patients (one female and three males) diagnosed with Alport syndrome. Visual acuity in the worst eye was between 20/40 and 20/60. All male patients had anterior lenticonus on biomicroscopy. The observed retinal findings included dots and flecks and pigmentary changes in the macula. On optical coherence tomography angiography, the inner retinal layers of all patients displayed thinning (especially in the temporal quadrant of the macula) and an increase in the foveal avascular zone. A thick choroid was observed in both eyes of the two youngest patients. Conclusions: In patients with Alport syndrome, the inner retinal layers suffer changes due to type IV collagen mutations. Optical coherence tomography angiography makes it possible to visualize and document these findings, making it a useful tool in the detection of early retinal findings associated with Alport syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|