Specificity Determinants in Neurotrophin-3 and Design of Nerve Growth Factor-Based trkC Agonists by Changing Central β-Strand Bundle Residues to Their Neurotrophin-3 Analogs

Autor:	Leonard G. Presta, Lori Y. O'Connell, Pantelis Tsoulfas, Roman Urfer
Rok vydání:	1997
Předmět:	Cell specific biology Chemistry Neurotrophin-3 Biochemistry Tropomyosin receptor kinase C Cell biology Nerve growth factor nervous system Neurotrophic factors Trk receptor biology.protein Binding site Receptor
Zdroj:	Biochemistry. 36:4775-4781
ISSN:	1520-4995 0006-2960
DOI:	10.1021/bi962877+
Popis:	Neurotrophic factors mediate their signal by binding to specific cell surface receptors of the trk family. The binding sites of neurotrophin-3 (NT-3) and nerve growth factor (NGF) to their preferre...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::46b62234b4b68701f3cac838b74f8438 https://doi.org/10.1021/bi962877+ Zobrazit plný text záznamu