Synthesis and Anti-HIV Activity of Prodrugs of Azidothymidine
| Autor: | A. P. Ollapally, A. P. Sharma, H. J. Lee |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
Anti hiv activity Chemistry viruses 030106 microbiology Human immunodeficiency virus (HIV) virus diseases General Medicine biochemical phenomena metabolism and nutrition Pharmacology Prodrug medicine.disease_cause 01 natural sciences Virology 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences Zidovudine Pharmacokinetics immune system diseases Infected cell medicine heterocyclic compounds medicine.drug |
| Zdroj: | Antiviral Chemistry and Chemotherapy. 4:93-96 |
| ISSN: | 2040-2066 |
| DOI: | 10.1177/095632029300400203 |
| Popis: | In order to enhance the therapeutic efficacy of azidothymidine (AZT) by improving its pharmacokinetic properties, three prodrugs of AZT were synthesized by esterifying the 5′-hydroxyl of AZT with three pharmacologically inactive steroidal 17β-carboxylic acids. Preliminary results of in vitro anti-HIV activity screening of the compounds show that all of these esters have anti-HIV activity comparable to that of AZT. This report discusses the synthesis and anti-HIV activity screening results of the prodrugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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