ChemInform Abstract: Solution-Phase Parallel Synthesis Using Ion-Exchange Resins

Autor:	Moorthy S. S. Palanki, Mark J. Suto, Leah M. Gayo-Fung, Robert Sullivan
Rok vydání:	2010
Předmět:	chemistry.chemical_compound stomatognathic system chemistry Reagent Amide technology industry and agriculture Urea Organic chemistry Amine gas treating General Medicine Ion-exchange resin Solution phase
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199830079
Popis:	Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. Several compound libraries have been prepared using the basic ion-exchange resin Amberlyst 21 as part of our lead optimization program. The utility of ion-exchange resins as a means of generating both large and small focused libraries will be reviewed. Acidic and basic ion-exchange resins are useful reagents in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins, and acidic ion-exchange resins have been used as selective amine scavengers in the synthesis of urea and amine libraries. The utility of ion-exchange resins as a means of generating focused libraries will be discussed.
Databáze:	OpenAIRE
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