| Popis: |
Although viruses from all genera within the Paramyxoviridae family antagonize the IFN response, there are a wide variety of mechanisms by which this antagonism occurs. It appears that viruses from both sub-families suppress the production of IFN via the V protein for members of the Paramyxovirinae and the NS proteins for members of the Pneumovirinae. Members of the Paramyxovirinae also use the V protein and/or other products of the viral P gene, such as C and W, to antagonize IFN signaling. Some of these viruses block both IFN-α/β and IFN-γ signaling pathways, whilst others block only IFN-α/β signaling by various mechanisms including interactions with the IFN receptor complex, targeted degradation of components of the signaling pathway and sequestration of signaling molecules in high molecular weight complexes. |
