Molecular characterization of chikungunya virus isolates from two localized outbreaks during 2014-2019 in Kerala, India

Autor: N T Nikhil, T Asia Devi, A P Sugunan, B Anukumar, Jijo Koshy
Rok vydání: 2021
Předmět:
Zdroj: Archives of Virology. 166:2895-2899
ISSN: 1432-8798
0304-8608
DOI: 10.1007/s00705-021-05186-9
Popis: After the 2005-2009 chikungunya epidemic, intermittent outbreaks were reported in many parts of India. The outbreaks were caused by either locally circulating strains or imported viruses. Virus transmission routes can be traced by complete genome sequencing studies. We investigated two outbreaks in 2014 and 2019 in Kerala, India. Chikungunya virus (CHIKV) was isolated from the samples, and whole genomes were sequenced for a 2014 isolate and a 2019 isolate. Phylogenetic analysis revealed that the isolates formed a separate group with a 2019 isolate from Pune, Maharashtra, and belonged to the East/Central/South African (ECSA) genotype, Indian subcontinent sublineage of the Indian Ocean Lineage (IOL). A novel mutation at amino acid position 76 of the E2 gene was observed in the group. The phylogenetic results suggest that the outbreaks might have been caused by a virus that had been circulating in India since 2014. A detailed study is needed to investigate the evolution of CHIKV in India.
Databáze: OpenAIRE
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