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Background: Codeine is a centrally acting cough suppressant and onset of action starts within minutes and peak concentration reaches within one hour. Aim: To evaluate the effect of codeine with paracetamol on coughing after flexible Bronchoscopy. Method: We enrolled patients in a randomised, open label, placebo controlled trail with codeine and paracetamol were given to the interventional group and paracetamol to the control group. We recorded demographic characteristics, indication, dose of propofol, xylocaine, induction time and duration of procedure. All major and minor adverse effects were noted. Primary outcome was Visual analogue scale (VAS) score for cough and secondary outcome were adverse effects like cough and pain. Result: Total of 137 patients were screened in the study from February 2018 to January 2019, of which 114 patients were enrolled. 58 patients were given condeine with paracetamol in interventional group and 56 patients were given paracetamol alone in control group. The mean age was 53 yrs in interventional group and 52 yrs in control group. Males/ Females were 40/18 and 38/ 18 respectively. Major induction for bronchoscopy were Lung Malignancies (27), Hemoptysis (18), COPD (15), Pneumonia (13) and other infiltrative disease (16). No patient required fluid resuscitation or endotracheal intubation. During the procedure, few minor complications like transient desaturation was observed. VAS for cough was 4.52 during and 1.98 after bronchoscopy in interventional group and 4.1 during and 1.98 after bronchoscopy group. Conclusion: There was no significant advantage of adding Codeine with paracetamol in suppressing cough during and after flexible bronchoscopy. |
