Photoinduced C(sp3)–H chlorination of amides with tetrabutyl ammonium chloride

Autor:	Wei Yu, Yanshuo Zhu
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Chlorine atom polycyclic compounds medicine Ammonium chloride Physical and Theoretical Chemistry Biochemistry Medicinal chemistry Chloride medicine.drug
Zdroj:	Organic & Biomolecular Chemistry. 19:10228-10232
ISSN:	1477-0539 1477-0520
DOI:	10.1039/d1ob02081a
Popis:	A new protocol was developed for the site-selective C(sp3)–H chlorination of amides with tetrabutyl ammonium chloride as the chlorinating agent. The reaction features a tandem sequence that involves a (diacetoxyiodo)benzene-mediated and chloride anion-involved N–H chlorination followed by photoinitiated chlorine atom transfer. A wide variety of carboxamides and sulfonamides were chlorinated at the δ-position by using this method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4685f57da5621dba86cad6769387e99a https://doi.org/10.1039/d1ob02081a Zobrazit plný text záznamu