Quantitative proton MRS of brain tumors reveals increased cholineT 2 in meningiomas
| Autor: | M. Lowry, D. J. Manton, S. J. Blackband, A. Horsman |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Tissue water
Radiological and Ultrasound Technology business.industry Relaxation (NMR) Biophysics computer.software_genre Creatine medicine.disease White matter Meningioma chemistry.chemical_compound medicine.anatomical_structure Nuclear magnetic resonance chemistry Voxel medicine Choline Radiology Nuclear Medicine and imaging Nuclear medicine business Proton mrs computer |
| Zdroj: | Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine. 2:361-363 |
| ISSN: | 1352-8661 |
| DOI: | 10.1007/bf01705272 |
| Popis: | Quantitative proton spectroscopy was performed on 26 volunteers and 9 patients using STEAM. Voxels (8 ml) were localized within white matter or meningioma and water-suppressed spectra acquired with TR=2 s at three echo times. Concentrations were calculated using individual relaxation parameter values with tissue water as an internal reference. Compared to white matter, meningiomas were characterized by an increased choline/creatine ratio, the absence ofN-acetylasparate, and the presence of alanine. Further, theT2 of choline and its concentration were both significantly greater in meningiomas than white matter (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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