Synthesis of novel N-glycoside derivatives via CuSCN-catalyzed reactions and their SGLT2 inhibition activities

Autor:	Xin-Shan Ye, Shao-Tao Bai, De-Cai Xiong, Youhong Niu, Yan-Fen Wu
Rok vydání:	2015
Předmět:	chemistry.chemical_classification chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Drug Discovery Triazole Click chemistry Glycoside Carbohydrate Biochemistry Coupling reaction Catalysis
Zdroj:	Tetrahedron. 71:4909-4919
ISSN:	0040-4020
Popis:	A convenient approach to the synthesis of novel triazole- N -glycoside derivatives was developed via CuSCN-catalyzed click reaction and Ullmann-type coupling reaction for the first time. The SGLT2 inhibitory activities of these synthetic N -glycosides were evaluated, and some compounds showed moderate SGLT2 inhibition activities at 100 nM. The results could benefit the discovery of new SGLT2 inhibitors for the treatment of diabetes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4674beb44a3307268b151b3acad64e62 https://doi.org/10.1016/j.tet.2015.05.108 Zobrazit plný text záznamu Full Text from ScienceDirect