Extranodal metastasis is a powerful prognostic factor in patients with adenocarcinoma of the esophagogastric junction
| Autor: | Hua Zhang, Zhen Tao Yu, Yong Yin Gao, Zhao Ma, Peng Tang, Chuan Gui Chen, Xiao Feng Duan, Hong Dian Zhang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Neoplasm Grading medicine.medical_specialty Multivariate analysis business.industry medicine.medical_treatment General Medicine medicine.disease Metastasis medicine.anatomical_structure Predictive value of tests Internal medicine medicine Adenocarcinoma Surgery Gastrectomy Stage (cooking) business Lymph node |
| Zdroj: | Journal of Surgical Oncology. 108:542-549 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.23430 |
| Popis: | Background and Objectives The purpose of this study is to estimate the effect of extranodal metastasis (EM) on recurrence and survival in patients with adenocarcinoma of the esophagogastric junction (AEG) after curative resection. Methods Clinical data from 284 node-positive AEG patients who underwent curative resection were reviewed. Univariate and multivariate analyses were conducted to elucidate the effect of EM on recurrence-free survival (RFS) and overall survival (OS). Results EM was detected in 70 (24.6%) of the 284 cases. It had a significant correlation with tumor size, Lauren type, histopathological grading, depth of tumor invasion, number of metastatic nodes, lymph node ratio, and TNM stage. The 5-year RFS and OS rates were 22.2% and 24.3%, respectively. Patients with EM had a significantly decreased RFS (16 vs. 36 months, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text