Lymphozyten-Subpopulationen in der bronchoalveolären Lavageflüssigkeit bei AIDS
| Autor: | U. Loos, B. Lüderitz, P. Hotz |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Aids patients
medicine.medical_specialty medicine.diagnostic_test Absolute number Lymphocytosis business.industry General Medicine respiratory system medicine.disease Gastroenterology Peripheral blood respiratory tract diseases Pneumonia Lymphocyte subpopulations Bronchoalveolar lavage Lung disease Internal medicine medicine medicine.symptom business |
| Zdroj: | DMW - Deutsche Medizinische Wochenschrift. 119:289-295 |
| ISSN: | 1439-4413 0012-0472 |
| DOI: | 10.1055/s-2008-1058693 |
| Popis: | Lymphocyte subpopulations in peripheral blood and bronchoalveolar lavage fluid (BAL) were examined in 29 patients with AIDS (26 men, three women; median age 32 [16-55] years). Patients in group 1 (n = 12) had no lung disease, in group 2 (n = 11) had Pneumocystis carinii pneumonia, in group 3 (n = 6) had other lung disease. There were 13 men and two women (median age 48 [21-80]) in the control group (bronchoscoped for mild pulmonary symptoms: no abnormal findings in the BAL). Compared with the control group, patients with AIDS had a significant deficiency in helper cells, both in blood (7-23% vs 50%; P < 0.01) as well as in the BAL (7-24% vs 52%; P < 0.001). There was a correlation of the percentage helper cell proportion in peripheral blood and BAL (for both group 1 and 2, rs = 0.75; P < 0.05). The proportion of helper cells in peripheral blood and BAL in AIDS patients was significantly lower in those with than without lung disease (group 1: 23% blood, 24% BAL vs group 2: 9% blood, 7% BAL; group 3: 7% blood, 7% BAL; P < 0.02 blood, P < 0.004 BAL). The percentage proportion of suppressor cells was greater in both blood and BAL in AIDS patients (group 1: blood 47%, BAL 63%; group 2: blood 44%, BAL 76%; group 3: blood 52%, BAL 75%) than in the controls (blood 28%, BAL 33% [P < 0.01], but there was no correlation between peripheral blood and BAL. In addition, the absolute number of suppressor cells in the lavage (30 cells/microliters in group 1 and 3, 65 cells/microliters in group 2) was significantly higher than in the controls (8 cells/microliters).--In AIDS patients there occurs a lymphocytosis in the BAL, while in blood there is a lymphopenia. The concordant decrease in helper cells in blood and BAL is decisive for the severity of any pulmonary infections. |
| Databáze: | OpenAIRE |
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