| Popis: |
ObjectiveTo determine whether entry into the canonical stage, canonical babbling ratios (CBR) and the level of volubility (vocal measures) are delayed in infants with Tuberous Sclerosis Complex (TSC), we completed human coding of their vocalizations at 12 months and compared the results to typically developing infants with no clinical features (TD/NCF).MethodsWe randomly selected videos from 40 infants with TSC from the TACERN database. All 78 videos were coded in real-time in AACT (Action Analysis, Coding and Training).ResultsEntry into thecanonical stagewas delayed in the great majority of the infants with TSC. TheCBRfor the TD/NCF infants was significantly higher than for the infants with TSC (TD/NCF mean = .346, SE = .19; TSC mean = .117, SE = .023).Volubilitylevel in infants with TSC was less than half that of TD/NCF infants (TD/NCF mean = 9.82, SE = 5.78; TSC mean = 3.99, SE = 2.16). CBR and volubility were also lower in TSC infants than in TD/NCF infants recorded all-day at home.ConclusionsEntry into the canonical stage was delayed, while canonical babbling ratios and volubility were low in infants with TSC. Assessing prediction of neurodevelopmental outcome using these vocal measures in combination with non-vocal measures will be the focus of planned studies in this high-risk population. |
