Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on Al–Mo gel
| Autor: | Hassan M. Rashed, Tamer M. Sakr, T. W. Fasih, Ahmed B. Ibrahim |
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| Rok vydání: | 2017 |
| Předmět: |
Chromatography
Lidocaine Chemistry Elution Health Toxicology and Mutagenesis Gel matrix Sodium channel Public Health Environmental and Occupational Health Post injection 010403 inorganic & nuclear chemistry 01 natural sciences Pollution Imaging agent 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Nuclear Energy and Engineering Biological profile medicine Radiology Nuclear Medicine and imaging Selectivity Spectroscopy medicine.drug |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 314:2091-2098 |
| ISSN: | 1588-2780 0236-5731 |
| DOI: | 10.1007/s10967-017-5560-z |
| Popis: | The current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al–99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. |
| Databáze: | OpenAIRE |
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