Enantioselective Copper-Catalyzed Conjugate Addition of Dimethylzinc to 5-(1-Arylalkylidene) Meldrum’s Acids

Autor:	Ashraf Wilsily, Eric Fillion, Tiantong Lou
Rok vydání:	2009
Předmět:	Phosphoramidite Ligand Organic Chemistry Dimethylzinc Substituent Enantioselective synthesis chemistry.chemical_element Meldrum's acid Copper Catalysis Stereocenter chemistry.chemical_compound chemistry Organic chemistry
Zdroj:	Synthesis. 2009:2066-2072
ISSN:	1437-210X 0039-7881
Popis:	The asymmetric formation of all-carbon quaternary benzylic stereocenters containing a methyl substituent was realized by the enantioselective copper-catalyzed 1,4-addition of dimethylzinc to alkylidene Meldrum's acids in the presence of a chiral phosphoramidite. Copper source and ligand optimization studies are presented, as well as the scope and limitations of dimethylzinc addition to various alkylidene Meldrum's acids. Good to excellent yields and enantioselectivities were obtained.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::465cfd84c41c06cf16790b0ff08fa821 https://doi.org/10.1055/s-0029-1216845 Zobrazit plný text záznamu