AB0078 Pulse methylprednisolone and cyclophosphamide therapy in three systemic lupus erythematosus patients with bronchiolitis obliterans organising pneumonia as the initial manifestation
| Autor: | RJ Hu, LY Lu, HH Cheng, JC Tseng |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Lung business.industry Interstitial lung disease Bronchiolitis obliterans Bronchiolitis obliterans organizing pneumonia Dermatomyositis medicine.disease Gastroenterology Polymyositis medicine.anatomical_structure Internal medicine medicine Histopathology Vasculitis business |
| Zdroj: | Speaker abstracts 2001. |
| Popis: | Background Diverse pleuropulmonary manifestations are common in patients with systemic lupus erythematosus (SLE). Bronchiolitis obliterans organising pneumonia (BOOP) is a pathologic entity characterised by the formation of fibrous plugs within terminal bronchioles and alveolar ducts. Although BOOP has been associated with several connective tissue disorders, there are rare reports of BOOP in patients with SLE as the initial manifestation. Objectives We describe three SLE patients with open lung biopsy-proved BOOP as the initial manifestation. Methods All three cases presented with acute/subacute chest symptoms of fever, cough and dyspnea. Chest radiographs and CT scan of lung revealed bilateral pulmonary infiltrates. BOOP was confirmed by open lung biopsy. Pulmonary vasculitis was also demonstrated in lung histopathology in one case. The pulmonary lesions and respiratory illnesses responded to pulse intravenous methylprednisolone and cyclophosphamide therapy. Results Conclusion References Otsuka F, Amano T, Hashimoto N, Takahashi M, Hayakawa N, Makino H, Ota Z, Ogura T. Bronchiolitis obliterans organizing peumonia associated with systemic lupus erythematosus with antiphospholipid antibody. Intern Med. 1996;35(4):341–4 Imasaki T, Yoshii A, Tanaka S, Ogura T, Ishikawa A, Takahashi T. Polymyositis and Sjogren’s syndrome associated with bronchiolitis obliterans organizing pneumonia. Intern Med. 1996;35(3):231–5 Min JK, Hong YS, Park SH, Park JH, Lee SH, Lee YS, Kim HH, Cho CS, Kim HY. Bronchiolitis obliterans organizing pneumonia as an initial manifestation with systemic lupus erythematosus. J Rheumatol. 1997;24(11):2254–7 Shinohara T, Hidaka T, Matsuki Y, Ishizuka T, Takamizawa M, Kawakami M, Kikuma H. Rapidly progressive interstitial lung disease associated with dermatomyositis responding to intravenous cyclophosphamide pulse therapy. Intern Med. 1997;36(7):519–23 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|