Abstract P5-13-01: Patterns of Breast Cancer Relapse According to Breast Cancer Subtypes in Lymph Node-Negative Breast Cancer — Results from International Breast Cancer Study Group Trials VIII and IX
| Autor: | R. D. Gelber, Zhuoxin Sun, A. Goldhirsch, Diana Crivellari, Fatima Cardoso, Raymond Snyder, Meredith M. Regan, Otto Metzger, A. S. Coates, G. Viale |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Gynecology
Cancer Research education.field_of_study medicine.medical_specialty business.industry Population Goserelin Cancer medicine.disease Lower risk Gastroenterology Basal (phylogenetics) medicine.anatomical_structure Breast cancer Oncology Internal medicine medicine education business Lymph node Tamoxifen medicine.drug |
| Zdroj: | Cancer Research. 70:P5-13 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Background: To explore the patterns of breast cancer (BC) relapse according to BC subtypes in a lower risk (lymph node (LN)-negative) population we classified pts from two trials according to a molecular classification using IHC surrogates. IBCSG Trial VIII randomized 1109 premenopausal pts with LN-negative BC to sequential treatment with six cycles of CMF followed by 18 months of goserelin, six courses of CMF alone, or 24 months of goserelin alone. The IBCSG Trial IX randomized 1669 postmenopausal pts with LN-negative BC to sequential treatment with 3 courses of CMF followed by tamoxifen for 57 months or tamoxifen alone for 5 years. Retrospective central pathology evaluation including ER, PgR, HER2 and Ki67 was used to define a molecular classification. Patients & Methods: Of the 2778 pts enrolled in both trials the present analysis includes 2033 (824 from trial VIII and 1209 from trial IX) who also had centrally-reviewed pathology data. The BC molecular subtypes were defined as following: Luminal-A (ER and/or PR-present, HER2-negative and Ki67 Results: In the population analyzed (N = 2033), 25.9% had luminal-A (LA) tumors, 40.3% had luminal B (LB) tumors, 17.7% had HER2-positive tumors, and 16.0% had basal tumors. At 12.7 years median follow-up, a total of 699 (34.4%) pts had BC recurrence or non-BC events (secondary malignancy or death): LA = 152 (28.8%), LB = 291 (35.5%), HER2- positive = 134 (37.2%), and Basal = 122 (37.4%). Among 2033 pts, no significant differences were observed among the molecular subtypes for time to local recurrence (LA 6.1%, LB 6.7%, HER2 7.8%, basal 6.7%, p = 0.98), contralateral BC (LA 3.4%, LB 4.1%, HER2 2.5%, basal 4.9%; p = 0.36), and non-BC events (LA 12%, LB 10%, HER2 8.3%, basal 7.7%; p=0.39). Patients with LB disease had more bone recurrences (LB 5.5%, LA 2.5%, HER2 3.3%, basal 1.8%; p=0.004). The patterns over time of soft tissue nodes and visceral recurrence varied according to the adjuvant treatment received (interaction tests P Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-13-01. |
| Databáze: | OpenAIRE |
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