1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole
| Autor: | Romano Silvestri, Marino Artico, Silvio Massa, Francesca Montis, Paolo La Colla, Tiziana Marceddu |
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| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Nitroimidazole biology Stereochemistry Organic Chemistry Clinical Biochemistry Nitro compound Pharmaceutical Science Ether Ring (chemistry) Biochemistry Chemical synthesis chemistry.chemical_compound chemistry Enzyme inhibitor Drug Discovery Nitro biology.protein Molecular Medicine Imidazole Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 10:253-256 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(99)00664-2 |
| Popis: | A novel family of non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentrations was discovered. The new derivatives are 1-[2-(diarylmethoxy)ethyl]imidazoles bearing substituents both at benzene and imidazole rings. The most potent derivatives were those having nitro and methyl groups as substituents in the imidazole ring. Among 10 test derivatives compound 6d was found to be as potent as nevirapine and was selected as a lead for further studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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