Memory CD8+ T cell responses to cancer
| Autor: | Christina V. Angeles, Jichang Han, Tyler G. Searles, Nikhil Khatwani, Mary Jo Turk |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Effector T cell Immunology Cancer Biology medicine.disease Phenotype 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immunity 030220 oncology & carcinogenesis medicine Immunology and Allergy Cytotoxic T cell Distribution (pharmacology) CD8 |
| Zdroj: | Seminars in Immunology. 49:101435 |
| ISSN: | 1044-5323 |
| DOI: | 10.1016/j.smim.2020.101435 |
| Popis: | Long-lived memory CD8+ T cells play important roles in tumor immunity. Studies over the past two decades have identified four subsets of memory CD8+ T cells - central, effector, stem-like, and tissue resident memory - that either circulate through blood, lymphoid and peripheral organs, or reside in tissues where cancers develop. In this article, we will review studies from both pre-clinical mouse models and human patients to summarize the phenotype, distribution and unique features of each memory subset, and highlight specific roles of each subset in anti-tumor immunity. Moreover, we will discuss how stem-cell like and resident memory CD8+ T cell subsets relate to exhausted tumor-infiltrating lymphocytes (TIL) populations. These studies reveal how memory CD8+ T cell subsets together orchestrate durable immunity to cancer. |
| Databáze: | OpenAIRE |
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