Rostral ventrolateral medulla catechol involvement upon sino-aortic deafferentation
| Autor: | N. Bruandet, L Quintin, N. Rentero |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Pentobarbital Catechol Chemistry Adrenergic General Medicine Rostral ventrolateral medulla General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Endocrinology In vivo Internal medicine medicine Reflex General Pharmacology Toxicology and Pharmaceutics Halothane Controlled hypotension medicine.drug |
| Zdroj: | Life Sciences. 68:177-189 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(00)00927-9 |
| Popis: | Pharmacologically-induced hypertension engages few aminergic ventrolateral medullary cells. To further address this issue, reflex hypertension evoked by acute sino-aortic deafferentation was chosen as a model. Adrenergic rostral ventrolateral neurons were recorded with a continuous, catechol-specific tool, i.e. in vivo voltammetry. Controlled hypotension led to the expected increase in catechol signal in sham rats (n=4) but not in deafferented (vagi, superior laryngeal and glossopharyngeal nerves) rats (n=5). Thus, the central responsiveness to known stimuli remained intact in this preparation following acute sino-aortic deafferentation. However, acute sino-aortic deafferentation itself induced no increase in catechol signal (n=4 or 5 respectively). No increase in catechol signal was observed when deafferentation was performed a) under hyperoxic conditions (O2=100%, n=5) b) by extensive deafferentation involving also the cervical sympathetic trunk under halothane (n=5) c) upon restrictive deafferentation leaving the vagi intact under pentobarbital (n=5) d) in decerebrate animals (n=4). Adrenergic rostral ventrolateral medullary barosensitive bulbospinal neurons may be primarily involved during hypotension. |
| Databáze: | OpenAIRE |
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