Leprosy associated with HLA-DR2 and DQwl in the population of northern Thailand
| Autor: | Vicharn Vithayasai, Kenrad E. Nelson, David Scollard, Olga Jonasson, V. Schauf, Arthur Brown, Treavor Smith, Sharon Ryan |
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| Rok vydání: | 2008 |
| Předmět: |
Hla class ii
education.field_of_study business.industry Immunology Population Tuberculoid leprosy General Medicine Immunogenetics bacterial infections and mycoses medicine.disease Biochemistry Relative risk Hla dr2 antigen Genetics Immunology and Allergy Medicine Leprosy business education Allele frequency |
| Zdroj: | Tissue Antigens. 26:243-247 |
| ISSN: | 1399-0039 0001-2815 |
| Popis: | A study of the frequency of HLA-DR2 and DQw1 was performed in leprosy patients and controls in northern Thailand. HLA-DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQw1. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection. |
| Databáze: | OpenAIRE |
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