In vitro anti-inflammatory potential and QSAR analysis of oxazolo/thiazolo pyrimidine derivatives

Autor:	Ramesh L. Sawant, Jyoti B. Wadekar, Charusheela A. Bansode
Rok vydání:	2012
Předmět:	Quantitative structure–activity relationship Pyrimidine Stereochemistry medicine.drug_class Organic Chemistry Carboxamide Ring (chemistry) In vitro Anti-inflammatory chemistry.chemical_compound chemistry medicine Polar effect Moiety General Pharmacology Toxicology and Pharmaceutics
Zdroj:	Medicinal Chemistry Research. 22:1884-1892
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-012-0189-5
Popis:	Twenty-six different benzylidene oxazolo/thiazolo (3,2-a)-pyrimidine-6-carboxamide derivatives were synthesized and evaluated for their anti-inflammatory potential by protein denaturation method. The structures of title compounds were characterized by IR and NMR spectral data. The SAR studies reveal that compounds containing electron withdrawing polar group at para position of 5-phenyl ring and electron withdrawing non-polar group at para position of 2-benzylidene moiety of thiazolo pyrimidine nucleus have better anti-inflammatory potential. The 2D-QSAR studies were performed on VLife MDS software which reveals that anti-inflammatory potential of benzylidene-3-oxo-5H-oxazolo/thiazolo (3,2-a)-pyrimidine-6-carboxamides is dependent on estate contribution, alignment independent, individual and path count descriptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::462f9e67130d583f9bb322e0d9ddb81c https://doi.org/10.1007/s00044-012-0189-5 Zobrazit plný text záznamu Full text from SpringerLink