Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands
Autor: | George R. Marshall, Michael Rowley, Sarah Grimwood, Paul D. Leeson, Mark Peter Ridgill, Neil Roy Curtis, Janusz Jozef Kulagowski, Ian M. Mawer |
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Rok vydání: | 1996 |
Předmět: | |
Zdroj: | Bioorganic & Medicinal Chemistry Letters. 6:1145-1150 |
ISSN: | 0960-894X |
Popis: | A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety. |
Databáze: | OpenAIRE |
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