Synthesis and SAR of diiodotyrosine-derived glycine-site N-methyl-D-aspartate receptor ligands

Autor:	George R. Marshall, Michael Rowley, Sarah Grimwood, Paul D. Leeson, Mark Peter Ridgill, Neil Roy Curtis, Janusz Jozef Kulagowski, Ian M. Mawer
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Diiodotyrosine Ligand Chemistry Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry Amino acid chemistry.chemical_compound Drug Discovery Glycine Molecular Medicine Moiety NMDA receptor Tyrosine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:1145-1150
ISSN:	0960-894X
Popis:	A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid function, having the (R) absolute stereochemistry, the 3,5-diiodo substituted aromatic ring and a lipophilic group attached at the phenolic oxygen of the tyrosine moiety.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::462c88d9948701fbd4341f4906cd036b https://doi.org/10.1016/0960-894x(96)00187-4 Zobrazit plný text záznamu Full Text from ScienceDirect