In vitro and in vivo trials of wearable artificial kidney
| Autor: | Nikita M. Zhilo, V. M. Grinval’d, B. M. Putrya, N. A. Bazaev, Evgeniy V. Streltsov |
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| Rok vydání: | 2018 |
| Předmět: |
Creatinine
Metabolite medicine.medical_treatment 030232 urology & nephrology Acute kidney injury Pharmacology medicine.disease Artificial kidney Peritoneal dialysis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry In vivo Urea medicine Uric acid 030212 general & internal medicine |
| Zdroj: | 2018 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus). |
| DOI: | 10.1109/eiconrus.2018.8317473 |
| Popis: | This paper presents results of in vitro and in vivo trials of a wearable artificial kidney (WAK) based on peritoneal dialysis. Materials and methods: in vitro trials were carried out in a developed test bench, which imitates patient's peritoneal cavity and capable to measure main procedure parameters. In vivo trial was carried out on a 15 kg dog in a healthy state to evaluate the effect of WAK on blood biochemical indicators and in an acute kidney injury state to test WAK's blood purification capabilities. Results: in vitro trials demonstrated that WAK could eliminate urea, uric acid and creatinine from spent dialysate with mean mass rates of 0.85±0.1 g/h, 0.10±0.04 g/h and 0.05±0.01 g/h respectively. Concentrations of Na+, Cl− and Ca2+ ions are kept in 10 % range from initial values. It is demonstrated that WAK can operate without replacement of expendable materials for 38 hours. During in vivo trial (39,5 hours), WAK performed continuous peritoneal dialysis with dialysis fluid regeneration. In acute kidney injury conditions (34 hours) creatinine and uric acid were eliminated from dialysing solution with the rate of 0,3 mg/h, urea was eliminated at the rate of 0,15 g/h, total removed ultrafiltrate volume was 350 ml. At the end of the second stage blood biochemical indicators stabilised in the range of normal values. Conclusion: developed WAK can perform elimination of metabolites from spent dialysis fluid with mass rates that are sufficient to maintain stable, physiologically normal metabolite concentrations in patient's blood. |
| Databáze: | OpenAIRE |
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