| Popis: |
Mitochondrial dysfunction has been implicated in the etiology of many drug-induced toxicities. Methotrexate (MTX), an antimetabolite and one of the folic acid antagonists, has widely been used to treat a variety of disorders such as cancer and several autoimmune disorders. It induces oxidative stress which results in many of its ill effects on different target and non-target organs, altering different metabolic pathways and interfering mitochondrial bioenergetics. Here, in our study, we have assessed the toxicity of methotrexate on rat liver mitochondria and its modulation by Morinda citrifolia L. (Noni) fruit extract. MTX significantly affects mitochondrial function, and activity of important mitochondrial enzymes such as Succinate dehydrogenase (SDH), Malate dehydrogenase (MDH) and NADH dehydrogenase. Reduced Cytochrome C – oxidase activity and Reduced glutathione (GSH) levels in MTX treated group (p |
