In Vivo Performance of an Injectable Biphasic Calcium Phosphate Bone Filler

Autor: Françoise Moreau, Guy Daculsi, Eric Aguado, Eric Goyenvalle, Serge Baroth, Pierre Layrolle
Rok vydání: 2008
Předmět:
Zdroj: Key Engineering Materials. :583-586
ISSN: 1662-9795
DOI: 10.4028/www.scientific.net/kem.396-398.583
Popis: An hydrated putty was prepared by mixing submicron particles, rounded particles and granules of Biphasic Calcium Phosphate (BCP) ceramics composed of HA and β-TCP phases. The material filled entirely critical sized defects in the femoral epiphysis of NZW rabbits. After 3, 6 and 12 weeks, histology revealed that submicron particles were rapidly degraded by multinucleated TRAP-positive cells. This osteoclastic resorption stimulated bone ingrowth while the large BCP particles served as scaffold supporting bone healing by osteoconduction.
Databáze: OpenAIRE