Post-treatment diagnostic accuracy of a new enzyme immunoassay to detect Helicobacter pylori in stools

Autor:	Francesco Costa, M.G. Mumolo, G. Maltinti, Massimo Bellini, M. R. Romano, Santino Marchi, A. Paci, M. Manghetti
Rok vydání:	2001
Předmět:	Breath test medicine.medical_specialty Hepatology biology medicine.diagnostic_test business.industry Spirillaceae Gastroenterology Rapid urease test Diagnostic accuracy Helicobacter pylori biology.organism_classification Confidence interval Surgery Internal medicine Immunoassay medicine Pharmacology (medical) Post treatment business
Zdroj:	Alimentary Pharmacology & Therapeutics. 15:395-401
ISSN:	0269-2813
Popis:	Background: Helicobacter pylori has attracted increasing attention among gastroenterologists because of its pathogenic potential, stimulating the search for non-invasive diagnostic tests. Aims: In this study the efficacy of a new enzyme immunoassay designed to detect H. pylori antigens in stools (HpSA) was evaluated before and after eradication therapy. Methods: HpSA was performed on stool samples collected from 268 patients whose H. pylori status was defined on the basis of concordant results for the 13C-urea breath test, rapid urease test and histology. The H. pylori-positive patients were treated with a 1-week triple therapy to eradicate the infection. One (T30) and 3 months (T90) after the end of therapy, 13C-urea breath test and HpSA were repeated in the treated patients. Results: The overall diagnostic accuracy of HpSA at T30 (83%, 95% confidence interval (CI) 77–89%) was significantly lower in comparison to the values obtained at baseline (94%, 95% CI: 91–97%) and at T90 (97%, 95% CI: 94–99%). No significant difference was found between the diagnostic accuracy of HpSA at baseline and at T90 (P=0.253). Conclusions: The present data suggest that HpSA provides a low diagnostic accuracy when used shortly after treatment. It needs a longer period of follow-up (8–12 weeks) to reach a reliability comparable to the 13C-urea breath test.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::461b61f02c39c0f6ccd5d1914890bc4a https://doi.org/10.1046/j.1365-2036.2001.00928.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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