Asymmetric synthesis of a novel phenylogous amino acid mimicking an extended dipeptide

Autor:	Lijing Chen, Richard V. Trilles, Jefferson Wright Tilley
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Allylic rearrangement Dipeptide Chemistry Stereochemistry Aryl Organic Chemistry Imine Enantioselective synthesis chemistry.chemical_element Biochemistry Amino acid chemistry.chemical_compound Bromide Drug Discovery Palladium
Zdroj:	Tetrahedron Letters. 36:8715-8718
ISSN:	0040-4039
Popis:	Synthesis of an orthogonally protected form of phenylogous amino acid 1 which mimics an extended conformation of the dipeptide Arg-Gly was achieved. Key steps Involve a diastereoselective addition of allylic organomelallic reagenlS to chira! imine 2 and a palladium mediated carboalkoxylation of aryl bromide 5.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4618ced595f3259c5936b5a760bac437 https://doi.org/10.1016/0040-4039(95)01877-k Zobrazit plný text záznamu Full Text from ScienceDirect