Hemophagocytosis and Histoplasma ‐like fungal infection in 32 cats
Autor: | Angela B. Royal, Deanna M. W. Schaefer, Theresa E. Rizzi |
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Rok vydání: | 2019 |
Předmět: |
030213 general clinical medicine
medicine.medical_specialty Hemophagocytic lymphohistiocytosis Hematology General Veterinary 040301 veterinary sciences Anemia business.industry 04 agricultural and veterinary sciences Neutropenia medicine.disease Pancytopenia Histoplasmosis 0403 veterinary science 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure hemic and lymphatic diseases Internal medicine Immunology medicine Bone marrow Hemophagocytosis business |
Zdroj: | Veterinary Clinical Pathology. 48:250-254 |
ISSN: | 1939-165X 0275-6382 |
Popis: | Histoplasmosis is one of the most common systemic fungal diseases in cats from the United States. It commonly causes respiratory or disseminated disease and is often associated with one or more cytopenias. Here, we describe 32 cats in which a Histoplasma-like fungal infection was associated with concurrent hemophagia in at least one sample site, commonly spleen, bone marrow, liver, and/or lymph node. The degree of hemophagia was characterized as moderate or marked in the majority of cases, and in all cases, there was a predominance of phagocytized mature erythrocytes. A few cases also had macrophages with phagocytized erythroid precursors, platelets, and/or neutrophils. Complete blood count results were available for 25 cats, and cytopenias were common (20/25), including solitary anemia (10), anemia and thrombocytopenia (5), solitary neutropenia (2), pancytopenia (2), and anemia and neutropenia (1). Bone marrow samples were only available in a small subset of cases, preventing the further assessment of the causes of the cytopenias. Hemophagocytosis has been previously reported in cats with neoplastic diseases and a cat with calicivirus infection, and likely occurs with other conditions as well, such as hemorrhage or hemolysis. Results of this report suggest that systemic fungal disease is an additional differential to consider when there is hemophagia in a feline cytology sample. |
Databáze: | OpenAIRE |
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