Improved chemoselectivity in intramolecular alkylidene carbene CH insertion

Autor:	Douglass F. Taber, Thomas E. Christos
Rok vydání:	1997
Předmět:	chemistry.chemical_compound Chemistry Intramolecular force Organic Chemistry Drug Discovery Chemoselectivity Selectivity Biochemistry Carbene Medicinal chemistry
Zdroj:	Tetrahedron Letters. 38:4927-4930
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(97)01081-2
Popis:	The alkylidene carbene generated by chloromethylenation / α-elimination of 1 proceeds with a high degree of selectivity for methoxy CH insertion over methine insertion, to give 2. The carbene generated with trimethylsilydiazomethane results in an approximately 1:1 mixture of 2 and 3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4614b6e4ad294a2dcb210659114f111a https://doi.org/10.1016/s0040-4039(97)01081-2 Zobrazit plný text záznamu Full Text from ScienceDirect