ChemInform Abstract: Synthesis of 3,6-Bicyclolides: A Novel Class of Macrolide Antibiotics

Autor:	Guoyou Xu, Zhe Wang, Datong Tang, Alexander Polemeropoulos, Yat Sun Or, Yonghua Gai, Zhigang Chen
Rok vydání:	2009
Předmět:	biology Bicyclic molecule medicine.drug_class Chemistry Antibiotics Erythromycin General Medicine biology.organism_classification Oxime Microbiology Macrolide Antibiotics chemistry.chemical_compound medicine.anatomical_structure In vivo medicine Bacteria Respiratory tract medicine.drug
Zdroj:	ChemInform. 40
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200916201
Popis:	The synthesis of 3,6-bicyclolides from erythromycin A oxime is described. This novel class of bridged bicyclic macrolides demonstrates potent in vitro and in vivo activities against a broad spectrum of bacteria including resistant respiratory tract pathogens.
Databáze:	OpenAIRE
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