Polyhydroxy Amino Acid Derivatives via β-Lactams Using Enantiospecific Approaches and Microwave Techniques

Autor:	Ajay K. Bose, Bimal K. Banik, Maghar S. Manhas, Dilip R. Wagle, Chandra Mathur
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Organic Chemistry Absolute configuration Polyoxamic acid Biochemistry Chemical reaction Amino acid Stereospecificity chemistry Drug Discovery β lactams Organic chemistry Enantiomer Microwave
Zdroj:	Tetrahedron. 56:5603-5619
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(00)00410-5
Popis:	Enantiospecific synthesis has been developed for α-hydroxy β-lactams of predictable absolute configuration starting with readily available carbohydrates. Stereospecific approaches and microwave assisted chemical reactions have been utilized for the preparation of these 3-hydroxy-2-azetidinones and their conversion to natural or non-natural enantiomeric forms of intermediates for gentosamine, 6-epi-lincosamine, γ-hydroxythreonine, and polyoxamic acid.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::45facf4243ffe323ace04525da4089c6 https://doi.org/10.1016/s0040-4020(00)00410-5 Zobrazit plný text záznamu Full Text from ScienceDirect