| Popis: |
An efficient enzymatic resolution of 7,7-disubstituted 1,4,5,6-tetrachlorobicyclo [2.2.1]hept-5-en-2-ols was accomplished by means of lipase AY-30 from Candida cylindracea in toluene. When acid anhydrides were used as acyl donors, the enantioselectivity was found to depend strongly on the reaction conditions: Whereas low selectivity (E 200). Alternatively, adsorption of the biocatalyst onto Celite was equally effective (E > 300). Complete specificity was obtained when vinyl acetate was used as acyl donor (E ∼ 1000). |
