N1-sterically hindered 2H-imidazol-2-one angiotensin II receptor antagonists: The conversion of surmountable antagonists to insurmountable antagonists
| Autor: | Maria A. Palomo, Danny J. Garland, Konrad F. Koehler, David B. Reitz, Monica B. Norton, Emily J. Reinhard, Gillian M. Olins, Susan T. Chen, Robert E. Manning, J. T. Collins, Ellen G. McMahon |
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| Rok vydání: | 1993 |
| Předmět: |
Steric effects
Angiotensin receptor Stereochemistry Organic Chemistry Clinical Biochemistry Antagonist Pharmaceutical Science Angiotensin II receptor antagonist Ring (chemistry) Biochemistry HYDIA chemistry.chemical_compound chemistry Competitive antagonist Drug Discovery Molecular Medicine Molecular Biology Methyl group |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1055-1060 |
| ISSN: | 0960-894X |
| Popis: | The surmountable (competitive) N 1 -(2-methylphenyl)-2H-imidazol-2-one angiotensin II receptor antagonist SC-54628 is converted to an insurmountable (noncompetitive) antagonist SC-54629 by the addition of a methyl group at the 6-position of the phenyl ring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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