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The aim of this study was to investigate the use of photodynamic therapy (PDT) using tin ethyl etiopurpurin (SnET2) for occluding the choriocapillaris in the eyes of pigmented rabbits. Following intravenous injection of SnET2 (0.5 and 1.0 mg/kg) or lipid emulsion alone, the fundus of pigmented rabbits was irradiated within 5 - 15 minutes of photosensitizer injection using 664 nm light at a fluence of 300 mW/cm2 and light doses of 5 - 20 J/cm2. Fundoscopy, fluorescein angiography (FA), and histology were performed at 1, 14 and 28 days after PDT. Following PDT, closure of choriocapillaris was achieved with light doses as low as 5 J/cm2 (17 seconds). Control eyes of rabbits demonstrated no effect to light irradiation at the parameters tested. PDT with SnET2 was effective in this animal model using low levels of activating light for the treatment of choriocapillaris.© (1996) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only. |
