HLA Class I Epitope Discovery in Type 1 Diabetes: Independent and Reproducible Identification of Proinsulin Epitopes of CD8 T Cells--Report of the IDS T Cell Workshop Committee

Autor:	Timothy Tree, Christian Boitard, Gabrielle G.M. Pinkse, Mark Peakman, Bart O. Roep
Rok vydání:	2006
Předmět:	geography geography.geographical_feature_category endocrine system diseases General Neuroscience T cell ELISPOT Human leukocyte antigen Biology Islet General Biochemistry Genetics and Molecular Biology Epitope Transplantation medicine.anatomical_structure History and Philosophy of Science Immunology medicine Cytotoxic T cell Proinsulin
Zdroj:	Annals of the New York Academy of Sciences. 1079:19-23
ISSN:	0077-8923
Popis:	Islet autoreactive CD8 T cells are plausible candidates for direct beta cell toxicity in type 1 diabetes (T1DM). In 2005, cellular studies in the pathogenesis of this disease have reached a new milestone. Autoreactive CD8 T cells have been defined and several target islet epitopes of these have been discovered and validated simultaneously in three independent studies. The insulin B10-B18 peptide that displays exceptional binding affinity for HLA-A2 has been reported in all three studies, and its recognition shows an association with autoimmune beta cell destruction and T1DM. These studies imply that CD8 T cell-based HLA tetramers and ELISPOT analyses can be useful to monitor T1DM as well as islet transplantation, and may provide useful tools to assess immunological efficacy of immune intervention trials.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::45cf3172acbaa68687823399018ea60e https://doi.org/10.1196/annals.1375.003 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.